Application

Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.

Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activationReactant for synthesis of: Antitubercular agents Anti-HIV-1 agents Aminopyrazine inhibitors Orally available naphthyridine protein kinase D inhibitors A Scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide

Precipitate may form upon standing which should not affect application.

General description

Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.

Packaging

25, 100 mL in glass bottle